Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats

Abstract Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of ac...

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Bibliographic Details
Main Authors: Ivana Perić, Victor Costina, Snežana Djordjević, Peter Gass, Peter Findeisen, Dragoš Inta, Stefan Borgwardt, Dragana Filipović
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97186-7