Inhibition of TDP-43 aggregation by nucleic acid binding.

Inhibition of TDP-43 aggregation by nucleic acid binding.

The aggregation of TAR DNA-binding protein (TDP-43) has been shown as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) since 2006. While evidence has suggested that mutation or truncation in TDP-43 influences its aggregation process, nevertheless, the co...

Full description

Bibliographic Details
Main Authors: Yi-Chen Huang, Ku-Feng Lin, Ruei-Yu He, Pang-Hsien Tu, Jiri Koubek, Yin-Chih Hsu, Joseph Jen-Tse Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3667863?pdf=render

Internet

http://europepmc.org/articles/PMC3667863?pdf=render

Similar Items