Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium

Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium

Abstract Background Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic genomes. However, it remains elusive why the ovarian epithelial cells are...

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Bibliographic Details
Main Authors: Liang Song, Zizhi Tang, Changsheng Peng, Yueming Yang, Chang Guo, Danqing Wang, Liandi Guo, Jie Chen, Cong Liu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
Ovarian surface epithelium
Steroid hormone
DNA damage
Homologous recombination
Online Access:http://link.springer.com/article/10.1186/s12885-020-07524-7

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http://link.springer.com/article/10.1186/s12885-020-07524-7

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