Visualizing conformation transitions of the Lipid II flippase MurJ

MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid II, a key player in bacterial cell wall synthesis, but the flipping mechanism remains poorly understood. Here authors report crystal structures of MurJ in different conformations which shed light on the MurJ transitions that med...

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Bibliographic Details
Main Authors: Alvin C. Y. Kuk, Aili Hao, Ziqiang Guan, Seok-Yong Lee
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09658-0