Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy

Abstract Background Myopathy and exercise intolerance are prominent clinical features in carriers of a point-mutation or large-scale deletion in the mitochondrial DNA (mtDNA). In the majority of patients, the mtDNA mutation is heteroplasmic with varying mutation loads between tissues of an individua...

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Bibliographic Details
Main Authors: Florence van Tienen, Ruby Zelissen, Erika Timmer, Marike van Gisbergen, Patrick Lindsey, Mattia Quattrocelli, Maurilio Sampaolesi, Elvira Mulder-den Hartog, Irenaeus de Coo, Hubert Smeets
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
mtDNA mutation
Mesoangioblasts
Muscle regeneration
Online Access:https://doi.org/10.1186/s13287-019-1510-8

Internet

https://doi.org/10.1186/s13287-019-1510-8

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