Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates.

Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates.

Down syndrome (DS) is the most frequent genetic cause of intellectual disability. Despite the fact that more than 50 years have passed since the discovery of its genetic aberrations, the exact pathogenesis of the DS phenotype has remained largely unexplained. It was recently hypothesized that the DS...

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Bibliographic Details
Main Authors: Peter Henneman, Arjan Bouman, Adri Mul, Lia Knegt, Anne-Marie van der Kevie-Kersemaekers, Nitash Zwaveling-Soonawala, Hanne E J Meijers-Heijboer, A S Paul van Trotsenburg, Marcel M Mannens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5877863?pdf=render

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http://europepmc.org/articles/PMC5877863?pdf=render

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