Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

To unravel the conflicting data concerning the dependence of human cholesterol biosynthesis on functional peroxisomes, we determined activities and levels of selected enzymes involved in cholesterol biosynthesis in livers of PEX5 knockout mice, a well-characterized model for human Zellweger syndrome...

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Bibliographic Details
Main Authors: Sietske Hogenboom, Gerrit Jan Romeijn, Sander M. Houten, Myriam Baes, Ronald J.A. Wanders, Hans R. Waterham
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Journal of Lipid Research
Subjects:
3-hydroxy-3-methylglutaryl coenzyme A reductase
isopentenyl pyrophosphate isomerase
isoprenoids
mevalonate kinase
mevalonate pyrophosphate decarboxylase
PEX5 mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520301917

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http://www.sciencedirect.com/science/article/pii/S0022227520301917

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