Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis

Abstract The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de novo synthesis of arginine, an impor...

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Bibliographic Details
Main Authors: Jonathan H. M. van der Meer, Ruben J. de Boer, Bartolomeus J. Meijer, Wouter L. Smit, Jacqueline L. M. Vermeulen, Sander Meisner, Manon van Roest, Pim J. Koelink, Evelien Dekker, Theodorus B. M. Hakvoort, Jan Koster, Lukas J. A. C. Hawinkels, Jarom Heijmans, Eduard A. Struijs, Marja A. Boermeester, Gijs R. van den Brink, Vanesa Muncan
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04173-x

Internet

https://doi.org/10.1038/s41419-021-04173-x

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