Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with Trypanosoma cruzi, the causative agent of Chagas disease, induces a polyclonal B-cel...

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Bibliographic Details
Main Authors: Livia Silva Araújo Passos, Luísa Mourão Dias Magalhães, Rodrigo Pinto Soares, Alexandre F. Marques, Marina Luiza Rodrigues Alves, Rodolfo Cordeiro Giunchetti, Maria do Carmo Pereira Nunes, Kenneth J. Gollob, Walderez Ornelas Dutra
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
B1 B-cells
Chagas disease
cardiomyopathy
Trypanosoma-cruzi
immunoregulation
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03015/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03015/full

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