The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense...

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Bibliographic Details
Main Authors: Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
macrophage
monocyte
THP-1 cells
differentiation
transcriptome
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00498/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00498/full

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