Structures of NS5 Methyltransferase from Zika Virus

The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp)....

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Bibliographic Details
Main Authors: Javier Coloma, Rinku Jain, Kanagalaghatta R. Rajashankar, Adolfo García-Sastre, Aneel K. Aggarwal
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312001