Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1). Recently, auto-antigens, such as desmocollins and others have been described in PV an...

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Bibliographic Details
Main Authors: Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
pemphigus
mouse model
desmocollin-3
desmoglein-3
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01387/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01387/full

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