Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools

Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools

The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event in the pathogenesis of different neurodegenerative disorders grouped under the term of synucleinopathies. They include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. To date,...

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Bibliographic Details
Main Authors: Silvia Paciotti, Giovanni Bellomo, Leonardo Gatticchi, Lucilla Parnetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
PMCA
RT-QuIC
α-synuclein
synucleinopathies
early diagnosis
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00415/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00415/full

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