Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System

Summary: Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical translation. Our data indicate that these iPSC-derived C...

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Bibliographic Details
Main Authors: Raul Vizcardo, Nicholas D. Klemen, S.M. Rafiqul Islam, Devikala Gurusamy, Naritaka Tamaoki, Daisuke Yamada, Haruhiko Koseki, Benjamin L. Kidder, Zhiya Yu, Li Jia, Amanda N. Henning, Meghan L. Good, Marta Bosch-Marce, Takuya Maeda, Chengyu Liu, Zied Abdullaev, Svetlana Pack, Douglas C. Palmer, David F. Stroncek, Fumito Ito, Francis A. Flomerfelt, Michael J. Kruhlak, Nicholas P. Restifo
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718302973

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http://www.sciencedirect.com/science/article/pii/S2211124718302973

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