In Chronic Hepatitis C Infection, Myeloid-Derived Suppressor Cell Accumulation and T Cell Dysfunctions Revert Partially and Late After Successful Direct-Acting Antiviral Treatment

In Chronic Hepatitis C Infection, Myeloid-Derived Suppressor Cell Accumulation and T Cell Dysfunctions Revert Partially and Late After Successful Direct-Acting Antiviral Treatment

Chronic HCV infection is characterized by several immunological alterations, such as the accumulation of suppressor cells and of hyperactivated T lymphocytes. However, it is unclear whether direct-acting antiviral (DAA)-mediated HCV clearance restores immune dysfunctions. We performed a phenotypic c...

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Bibliographic Details
Main Authors: Valentina Telatin, Francesco Nicoli, Chiara Frasson, Nicola Menegotto, Francesco Barbaro, Eleonora Castelli, Elke Erne, Giorgio Palù, Antonella Caputo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HCV
DAA
M-MDCSs
Tregs
T lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00190/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00190/full

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