Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochon...

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Bibliographic Details
Main Authors: Ying Ann Chiao, Huiliang Zhang, Mariya Sweetwyne, Jeremy Whitson, Ying Sonia Ting, Nathan Basisty, Lindsay K Pino, Ellen Quarles, Ngoc-Han Nguyen, Matthew D Campbell, Tong Zhang, Matthew J Gaffrey, Gennifer Merrihew, Lu Wang, Yongping Yue, Dongsheng Duan, Henk L Granzier, Hazel H Szeto, Wei-Jun Qian, David Marcinek, Michael J MacCoss, Peter Rabinovitch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
mitochondria
aging
cardiac function
oxidative stress
diastolic dysfunction
Online Access:https://elifesciences.org/articles/55513

Internet

https://elifesciences.org/articles/55513

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