19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism

19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism

CONTEXT AND OBJECTIVE: Polymorphisms in genes involved in folate metabolism may modulate the maternal risk of Down syndrome (DS). This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase (DHFR) gene on the maternal risk of DS, and inv...

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Bibliographic Details
Main Authors: Cristiani Cortez Mendes, Joice Matos Biselli, Bruna Lancia Zampieri, Eny Maria Goloni-Bertollo, Marcos Nogueira Eberlin, Renato Haddad, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Érika Cristina Pavarino-Bertelli
Format: Article
Language:English
Published: Associação Paulista de Medicina
Series:São Paulo Medical Journal
Subjects:
Down syndrome
Polymorphism, genetic
Folic acid
Nondisjunction, genetic
Risk factors
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000400008&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000400008&lng=en&tlng=en

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