Identification and characterization of MYH9 locus for high efficient gene knock-in and stable expression in mouse embryonic stem cells.

Identification and characterization of MYH9 locus for high efficient gene knock-in and stable expression in mouse embryonic stem cells.

Targeted integration of exogenous genes into so-called safe harbors/friend sites, offers the advantages of expressing normal levels of target genes and preventing potentially adverse effects on endogenous genes. However, the ideal genomic loci for this purpose remain limited. Additionally, due to th...

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Bibliographic Details
Main Authors: Tanbin Liu, Yi Hu, Shiyin Guo, Lei Tan, Yang Zhan, Lingchen Yang, Wei Liu, Naidong Wang, Yalan Li, Yingfan Zhang, Chengyu Liu, Yi Yang, Robert S Adelstein, Aibing Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5811019?pdf=render

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http://europepmc.org/articles/PMC5811019?pdf=render

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