A new methodology for polyvalent intravenous immunoglobulin solution production with a two-stage process of viral inactivation

A new methodology for polyvalent intravenous immunoglobulin solution production with a two-stage process of viral inactivation

Highly purified intravenous immunoglobulin G concentrate (IV IgG) was produced with the use of polyethylene glycol associated to a single-stage precipitation by ethanol, instead of the classic Cohn-Oncley process, which employs cold alcohol as the precipitating agent, in a three-stage process. Preci...

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Bibliographic Details
Main Authors: Antônio Edson de Souza Lucena, Divaldo de Almeida Sampaio, Ednaldo Rosas da Silva, Virgínia Florêncio de Paiva, Ana Cláudia Santiago, Ana Cristina Lima Leite
Format: Article
Language:English
Published: Universidade de São Paulo 2010-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Hemoderivados
Imunoglobulinas
Polietilenoglicol
Ultrafiltração
Cromatografia de troca iônica
Blood derivatives
Immunoglobulins
Polyethylene glycol
Ultrafiltration
Ion exchange chromatography
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400020

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400020

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