Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

Objective: Retinal ischemic disease is a major cause of vision loss. Current treatment options are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not fully understood. We have previously shown that the deletion of the mitochondrial arginase isoform, arginase 2...

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Bibliographic Details
Main Authors: Esraa Shosha, Abdelrahman Y. Fouda, Tahira Lemtalsi, Stephen Haigh, David Fulton, Ahmed Ibrahim, Mohamed Al-Shabrawey, R. William Caldwell, Ruth B. Caldwell
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Retina
Ischemia
Arginase
Endothelial cells
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001186

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http://www.sciencedirect.com/science/article/pii/S2212877821001186

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