AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections

AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections

Abstract Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it is not known if this ev...

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Bibliographic Details
Main Authors: Nathaniel B. Bone, Eugene J. Becker, Maroof Husain, Shaoning Jiang, Anna A. Zmijewska, Dae-Won Park, Balu Chacko, Victor Darley-Usmar, Murielle Grégoire, Jean-Marc Tadie, Victor J. Thannickal, Jaroslaw W. Zmijewski
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90573-0

Internet

https://doi.org/10.1038/s41598-021-90573-0

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