A Soft Coral Natural Product, 11-Episinulariolide Acetate, Inhibits Gene Expression of Cyclooxygenase-2 and Interleukin-8 through Attenuation of Calcium Signaling

A Soft Coral Natural Product, 11-Episinulariolide Acetate, Inhibits Gene Expression of Cyclooxygenase-2 and Interleukin-8 through Attenuation of Calcium Signaling

Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancer cells. EGFR-mediated signaling involves inflammatory gene expression including cyclooxygenase (COX)-2 and interleukin (IL)-8, and is associated with cancer pathogenesis. In a search of phytochemicals with anti-inflammat...

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Bibliographic Details
Main Authors: Wei-Chiao Chang, Chiung-Yao Huang, Jyh-Horng Sheu, Ming-Feng Hou, Eric Terry Wang, Che-Mai Chang, Jaw-Yan Wang, Wen-Li Hsu, Siou-Jin Chiu, Yao-Ting Tsai
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
marine compound
EGF
COX-2
IL-8
calcium
Online Access:http://www.mdpi.com/1420-3049/18/6/7023

Internet

http://www.mdpi.com/1420-3049/18/6/7023

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