In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1 and Costello syndrome.

In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1 and Costello syndrome.

Defects in the rat sarcoma viral oncogene homolog (Ras)/extracellular-signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling pathways are responsible for several neurodevelopmental disorders. These disorders are an important cause fo...

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Bibliographic Details
Main Authors: Tiantian eWang, Laura eKok, Rob eWillemsen, Ype eElgersma, Gerard eBorst
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Intellectual Disability
Synaptic Transmission
H-ras
short-term plasticity
Autism Spectrum Disorders
calyx of held
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00234/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00234/full

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