Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus

Abstract The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain. Netrin-1 recruits GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) and is crit...

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Bibliographic Details
Main Authors: Stephen D. Glasgow, Edwin W. Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe Séguéla, Edward S. Ruthazer, Timothy E. Kennedy
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Molecular Brain
Subjects:
CA1 pyramidal neurons
Schaffer collaterals
Long-term potentiation
Axon guidance
Spatial memory
SHANK
Online Access:http://link.springer.com/article/10.1186/s13041-020-00597-2

Internet

http://link.springer.com/article/10.1186/s13041-020-00597-2

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