Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis

Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis

Professional phagocytes engulf microbial invaders into plasma membrane-derived phagosomes. These mature into microbicidal phagolysosomes, leading to killing of the ingested microbe. Phagosome maturation involves sequential fusion of the phagosome with early endosomes, late endosomes, and the main de...

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Bibliographic Details
Main Authors: Andreas Jeschke, Albert Haas
Format: Article
Language:English
Published: Taylor & Francis Group 2016-05-01
Series:Communicative & Integrative Biology
Subjects:
cell-free membrane fusion
intracellular pathogens
lysosome
phagolysosome
phagosome maturation
phosphatidylinositol 3-phosphate
phosphatidylinositol 4-phosphate
phosphinositide
PI(3)P
PI(4)P
Online Access:http://dx.doi.org/10.1080/19420889.2016.1174798

Internet

http://dx.doi.org/10.1080/19420889.2016.1174798

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