Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1

Aberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1

Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells contributes to malignancy through suppression of the T cell-mediated antitumor response. Pyruvate dehydrogenase kinase 1 (PDK1), a...

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Bibliographic Details
Main Authors: Jing-Jing Wang, Michelle K. Siu, Yu-Xin Jiang, Thomas H. Leung, David W. Chan, Ran-Ran Cheng, Annie N. Cheung, Hextan Y. Ngan, Karen K. Chan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
ovarian cancer
pdk1
pd-l1
pd-1
cd8+ t cell
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1659092

Internet

http://dx.doi.org/10.1080/2162402X.2019.1659092

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