Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report

Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report

Isocitrate Dehydrogenase-1 (IDH1) is a driver gene in several cancers including brain tumors such as low-grade and high-grade gliomas. Mutations of SMARCB1 were described in atypical teratoid rhabdoid tumors and to date have not been associated with the pathogenesis of medulloblastoma. We report con...

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Bibliographic Details
Main Authors: Moatasem El-Ayadi, Kristof Egervari, Doron Merkler, Thomas A. McKee, Fabienne Gumy-Pause, Damian Stichel, David Capper, Torsten Pietsch, Marc Ansari, André O. von Bueren
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neurology
Subjects:
medulloblastoma
IDH-1
SMARCB1
SHH activation
pediatric
mutation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00398/full

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https://www.frontiersin.org/article/10.3389/fneur.2018.00398/full

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