Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling

Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling

Grifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240 μmol/L (hyperuricemia control, P < .01) to 17...

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Bibliographic Details
Main Authors: Tianqiao Yong, Yizhen Xie, Shaodan Chen, Diling Chen, Jiyan Su, Chunwei Jiao, Huiping Hu, Chun Xiao
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Functional Foods
Subjects:
Grifola frondosa
Hyperuricemia
Urate transporter 1
3D QSAR pharmacophore
Virtual screening
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617307211

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http://www.sciencedirect.com/science/article/pii/S1756464617307211

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