Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling

Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling

Grifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240 μmol/L (hyperuricemia control, P < .01) to 17...

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Main Authors: Tianqiao Yong, Yizhen Xie, Shaodan Chen, Diling Chen, Jiyan Su, Chunwei Jiao, Huiping Hu, Chun Xiao
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Functional Foods
Subjects:
Grifola frondosa
Hyperuricemia
Urate transporter 1
3D QSAR pharmacophore
Virtual screening
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617307211
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spelling doaj-7239c2d01cc9499e94e63f5de29a87cb2021-04-30T07:12:26ZengElsevierJournal of Functional Foods1756-46462018-01-0140582588Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modelingTianqiao Yong0Yizhen Xie1Shaodan Chen2Diling Chen3Jiyan Su4Chunwei Jiao5Huiping Hu6Chun Xiao7State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; Guangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, China; Corresponding author at: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; Guangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; Guangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaGuangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; Guangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, ChinaGrifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240 μmol/L (hyperuricemia control, P < .01) to 170, 169, and 153 μmol/L for GFW at doses of 30, 60, and 120 mg/kg and to 169, 168, and 156 μmol/L for GFE at 50, 100, and 200 mg/kg correspondingly, which were similar to the normal control (159 μmol/L). ELISA analysis demonstrated the inhibitory effects of GFW and GFE on URAT1 protein rather than xanthine oxidase (XOD). The 3D-QSAR pharmacophore model for URAT1 was established successfully. Four compounds were identified and mapped adequately, deserving further study. Taken together, G. frondosa is a promising candidate for the development of functional foods.http://www.sciencedirect.com/science/article/pii/S1756464617307211Grifola frondosaHyperuricemiaUrate transporter 13D QSAR pharmacophoreVirtual screening
collection DOAJ
language English
format Article
sources DOAJ
author Tianqiao Yong
Yizhen Xie
Shaodan Chen
Diling Chen
Jiyan Su
Chunwei Jiao
Huiping Hu
Chun Xiao
spellingShingle Tianqiao Yong
Yizhen Xie
Shaodan Chen
Diling Chen
Jiyan Su
Chunwei Jiao
Huiping Hu
Chun Xiao
Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
Journal of Functional Foods
Grifola frondosa
Hyperuricemia
Urate transporter 1
3D QSAR pharmacophore
Virtual screening
author_facet Tianqiao Yong
Yizhen Xie
Shaodan Chen
Diling Chen
Jiyan Su
Chunwei Jiao
Huiping Hu
Chun Xiao
author_sort Tianqiao Yong
title Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
title_short Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
title_full Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
title_fullStr Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
title_full_unstemmed Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
title_sort hypouricemic effect of grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3d qsar pharmacophore modeling
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2018-01-01
description Grifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240 μmol/L (hyperuricemia control, P < .01) to 170, 169, and 153 μmol/L for GFW at doses of 30, 60, and 120 mg/kg and to 169, 168, and 156 μmol/L for GFE at 50, 100, and 200 mg/kg correspondingly, which were similar to the normal control (159 μmol/L). ELISA analysis demonstrated the inhibitory effects of GFW and GFE on URAT1 protein rather than xanthine oxidase (XOD). The 3D-QSAR pharmacophore model for URAT1 was established successfully. Four compounds were identified and mapped adequately, deserving further study. Taken together, G. frondosa is a promising candidate for the development of functional foods.
topic Grifola frondosa
Hyperuricemia
Urate transporter 1
3D QSAR pharmacophore
Virtual screening
url http://www.sciencedirect.com/science/article/pii/S1756464617307211
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