Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells

Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells

UT2 cells are a mutant clone of Chinese hamster ovary (CHO) cells that are deficient in the 97 kDa endoplasmic reticulum (ER) 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase protein. The analysis of UT2 cell cDNA and genomic DNA has led to the identification of two novel point mutations in...

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Bibliographic Details
Main Authors: William Harrison Engfelt, Kimberly R. Masuda, Vincent G. Paton, Skaidrite K. Krisans
Format: Article
Language:English
Published: Elsevier 1998-11-01
Series:Journal of Lipid Research
Subjects:
cholesterol
endoplasmic reticulum
peroxisomes
90 kDa peroxisomal reductase
Chinese hamster ovary cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324731

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http://www.sciencedirect.com/science/article/pii/S0022227520324731

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