Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

Abstract Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 is also the pyruvate kinase isoform expressed in most wild-type adul...

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Bibliographic Details
Main Authors: Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden, Tyler Jacks
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Cancer & Metabolism
Subjects:
PKM2
Soft tissue sarcoma
Cancer
Online Access:http://link.springer.com/article/10.1186/s40170-018-0179-2

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http://link.springer.com/article/10.1186/s40170-018-0179-2

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