How Smoking Cessation Influence Hormonal Levels in Postmenopausal Women?

Smoking represents the most widespread substance dependence in the world. Nicotine alters women hormonal homeostasis. Women smokers have higher testosterone and lower estradiol levels throughout life compared to non-smokers. We monitored the effect of smoking discontinuation on steroid spectrum with...

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Bibliographic Details
Main Authors: Hana Jandíková, Michaela Dušková, Kateřina Šimůnková, Beáta Rácz, Martin Hill, Hana Pospíšilová, Alexandra Kmeťová, Eva Králíková, Karel Vondra, Luboslav Stárka
Format: Article
Language:English
Published: Karolinum Press 2014-01-01
Series:Prague Medical Report
Subjects:
Online Access:https://pmr.lf1.cuni.cz/115/1/0060/
Description
Summary:Smoking represents the most widespread substance dependence in the world. Nicotine alters women hormonal homeostasis. Women smokers have higher testosterone and lower estradiol levels throughout life compared to non-smokers. We monitored the effect of smoking discontinuation on steroid spectrum with 25 postmenopausal women smokers. They had been examined before discontinuation of smoking and after 6, 12, 24 and 48 weeks of abstinence. Blood was collected to determine steroid spectrum (measured by GC-MS), luteinizing hormone, follicle stimulating hormone and sex hormone binding globulin (measured by IRMA). Repeated measures ANOVA model was used for evaluation of the data. In postmenopausal women, an increase in testosterone, dihydrotestosterone, dehydroepiandrosterone and other androgens occurred. Neither nicotine replacement therapy nor weight changes nor age play a role in androgen level increase. The higher androgens levels correlated with failure in smoking cessation. Women smokers have higher androgen levels, which might play a role in smoking dependence development. Women successful in smoking cessation, compared to the non-successful ones, have lower androgen levels initially and also after smoking discontinuation.
ISSN:1214-6994
2336-2936