Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

The oncogene DJ-1 has been originally identified as a suppressor of PTEN. Further on, loss-of-function mutations have been described as a causative factor in Parkinson's disease (PD). DJ-1 has an important function in cellular antioxidant responses, but its role in central metabolism of neurons...

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Main Authors: J. Meiser, S. Delcambre, A. Wegner, C. Jäger, J. Ghelfi, A. Fouquier d'Herouel, X. Dong, D. Weindl, C. Stautner, Y. Nonnenmacher, A. Michelucci, O. Popp, F. Giesert, S. Schildknecht, L. Krämer, J.G. Schneider, D. Woitalla, W. Wurst, A. Skupin, D.M. Vogt Weisenhorn, R. Krüger, M. Leist, K. Hiller
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Mitochondrial metabolism
Glutamine
Serine
Folate mediated one-carbon metabolism
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300195

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http://www.sciencedirect.com/science/article/pii/S0969996116300195

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