Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI

Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI

Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells. If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatm...

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Bibliographic Details
Main Authors: Song-Tao Wu, Bo Liu, Zhong-Zhu Ai, Zong-Chao Hong, Peng-Tao You, He-Zhen Wu, Yan-Fang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
glycolysis
esculetin
proteomics
microscale thermophoresis
transcriptome
protein inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00379/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00379/full

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