A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents

A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents

The dynamics of hepatitis C virus (HCV) RNA during translation and replication within infected cells were added to a previous age-structured multiscale mathematical model of HCV infection and treatment. The model allows the study of the dynamics of HCV RNA inside infected cells as well as the releas...

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Bibliographic Details
Main Authors: Barbara de M. Quintela, Jessica M. Conway, James M. Hyman, Jeremie Guedj, Rodrigo W. dos Santos, Marcelo Lobosco, Alan S. Perelson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
computational biology
HCV
RNA
DAAs
differential equations
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00601/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00601/full

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