Deep neural networks for inferring binding sites of RNA-binding proteins by using distributed representations of RNA primary sequence and secondary structure

Deep neural networks for inferring binding sites of RNA-binding proteins by using distributed representations of RNA primary sequence and secondary structure

Abstract Background RNA binding proteins (RBPs) play a vital role in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport, and modulation of mRNA translation and decay. The identification of RBP binding sites is a crucial step in understanding the biological...

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Bibliographic Details
Main Authors: Lei Deng, Youzhi Liu, Yechuan Shi, Wenhao Zhang, Chun Yang, Hui Liu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Genomics
Subjects:
RNA-binding proteins
Binding sites
Distributed representation
k-mer
Deep learning
Convolutional neural network
Online Access:https://doi.org/10.1186/s12864-020-07239-w

Internet

https://doi.org/10.1186/s12864-020-07239-w

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