A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI

A 7-Deazaadenosylaziridine Cofactor for Sequence-Specific Labeling of DNA by the DNA Cytosine-C5 Methyltransferase M.HhaI

DNA methyltransferases (MTases) catalyze the transfer of the activated methyl group of the cofactor S-adenosyl-l-methionine (AdoMet or SAM) to the exocyclic amino groups of adenine or cytosine or the C5 ring atom of cytosine within specific DNA sequences. The DNA adenine-N6 MTase from Thermus aquati...

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Bibliographic Details
Main Authors: Falk Kunkel, Rudi Lurz, Elmar Weinhold
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
S-adenosyl-l-methionine
AdoMet
aziridine
CpG methylation
cofactor
7-deazaadenosine derivative
DNA methyltransferase
DNA methylation
DNA labeling
Sonogashira coupling
SAM
Online Access:http://www.mdpi.com/1420-3049/20/11/19723

Internet

http://www.mdpi.com/1420-3049/20/11/19723

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