Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Respiratory complex I inhibition by drugs and other chemicals has been implicated as a frequent mode of mitochondria-mediated cell injury. However, the exact mechanisms leading to the activation of cell death pathways are incompletely understood. This study was designed to explore the relative cont...

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Bibliographic Details
Main Authors: Naoki Imaizumi, Kang Kwang Lee, Carmen Zhang, Urs A. Boelsterli
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715000063