Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing β-amyloid precursor protein (APP) under control of the platelet-derived growth factor...

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Bibliographic Details
Main Authors: Sheng-Kwei Song, Joong Hee Kim, Shiow-Jiuan Lin, Robert P. Brendza, David M. Holtzman
Format: Article
Language:English
Published: Elsevier 2004-04-01
Series:Neurobiology of Disease
Subjects:
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002687