Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition
Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing β-amyloid precursor protein (APP) under control of the platelet-derived growth factor...
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| Format: | Article |
| Language: | English |
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Elsevier
2004-04-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103002687 |
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doaj-7251f5a456094ab89061963d88adcd6b |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sheng-Kwei Song Joong Hee Kim Shiow-Jiuan Lin Robert P. Brendza David M. Holtzman |
| spellingShingle |
Sheng-Kwei Song Joong Hee Kim Shiow-Jiuan Lin Robert P. Brendza David M. Holtzman Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition Neurobiology of Disease Alzheimer's disease Diffusion tensor Mice PDAPP MRI Myelin |
| author_facet |
Sheng-Kwei Song Joong Hee Kim Shiow-Jiuan Lin Robert P. Brendza David M. Holtzman |
| author_sort |
Sheng-Kwei Song |
| title |
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| title_short |
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| title_full |
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| title_fullStr |
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| title_full_unstemmed |
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| title_sort |
diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition |
| publisher |
Elsevier |
| series |
Neurobiology of Disease |
| issn |
1095-953X |
| publishDate |
2004-04-01 |
| description |
Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing β-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid β (Aβ) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI. |
| topic |
Alzheimer's disease Diffusion tensor Mice PDAPP MRI Myelin |
| url |
http://www.sciencedirect.com/science/article/pii/S0969996103002687 |
| work_keys_str_mv |
AT shengkweisong diffusiontensorimagingdetectsagedependentwhitematterchangesinatransgenicmousemodelwithamyloiddeposition AT joongheekim diffusiontensorimagingdetectsagedependentwhitematterchangesinatransgenicmousemodelwithamyloiddeposition AT shiowjiuanlin diffusiontensorimagingdetectsagedependentwhitematterchangesinatransgenicmousemodelwithamyloiddeposition AT robertpbrendza diffusiontensorimagingdetectsagedependentwhitematterchangesinatransgenicmousemodelwithamyloiddeposition AT davidmholtzman diffusiontensorimagingdetectsagedependentwhitematterchangesinatransgenicmousemodelwithamyloiddeposition |
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1724212130993930240 |
| spelling |
doaj-7251f5a456094ab89061963d88adcd6b2021-03-20T04:49:16ZengElsevierNeurobiology of Disease1095-953X2004-04-01153640647Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid depositionSheng-Kwei Song0Joong Hee Kim1Shiow-Jiuan Lin2Robert P. Brendza3David M. Holtzman4Department of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Chemistry, Washington University, St. Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USAIncreasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing β-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid β (Aβ) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI.http://www.sciencedirect.com/science/article/pii/S0969996103002687Alzheimer's diseaseDiffusion tensorMicePDAPPMRIMyelin |