Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression

Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression

Induced pluripotent stem cells formed by the introduction of only three factors, Oct4/Sox2/Klf4 (3-gene iPSCs), may provide a safer option for stem cell-based therapy than iPSCs conventionally introduced with four-gene iPSCs. Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) p...

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Bibliographic Details
Main Authors: Yi-Jen Chen, Chia-Hua Kuo, Hsin-Chen Lee, Ming-Chi Yung, Chuan-Chih Hsu, Kai-Hsi Lu, Shin-Da Lee, Chin-Hong Chang, Wen-Shin Song, Chi-Hsien Peng, Kuan-Hsuan Chen, Yueh Chien, Yuh-Lih Chang, Yueh-Ching Chou, Pin-I Huang
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:International Journal of Molecular Sciences
Subjects:
induced pluripotent stem cell
c-Myc
peroxisome proliferator-activated receptor gamma coactivator-1α
brown adipocyte
Online Access:http://www.mdpi.com/1422-0067/12/11/7554/

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http://www.mdpi.com/1422-0067/12/11/7554/

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