Efficient fidelity control by stepwise nucleotide selection in polymerase elongation Abstract: Polymerases select nucleotides
Polymerases select nucleotides according to a template before incorporating them for chemical synthesis during gene replication or transcription. Efficient selection to achieve sufficiently high fidelity and speed is essential for polymerase function. Due to multiple kinetic steps detected in a poly...
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| Format: | Article |
| Language: | English |
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De Gruyter
2014-01-01
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| Series: | Computational and Mathematical Biophysics |
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| Online Access: | https://doi.org/10.2478/mlbmb-2014-0010 |