A pilot protocol to assess the feasibility of a virtual multiple crossover, randomized controlled trial design using methylphenidate in mild cognitive impairment

A pilot protocol to assess the feasibility of a virtual multiple crossover, randomized controlled trial design using methylphenidate in mild cognitive impairment

Abstract Background The conventional clinical trial design in Alzheimer’s disease (AD) and AD-related disorders (ADRDs) is the parallel-group randomized controlled trial. However, in heterogeneous disorders like AD/ADRDs, this design requires large sample sizes to detect meaningful effects in an “av...

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Bibliographic Details
Main Authors: Libby A. DesRuisseaux, Victoria J. Williams, Alison J. McManus, Anoopum S. Gupta, Becky C. Carlyle, Hamed Azami, Jessica A. Gerber, Anna M. Bolling, Carolyn L. Cook, Rebecca A. Betensky, Steven E. Arnold
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Trials
Subjects:
Multiple crossover trial
Alzheimer’s disease
Mild cognitive impairment
Clinical trial design
Methylphenidate
Virtual trial
Online Access:https://doi.org/10.1186/s13063-020-04752-x

Internet

https://doi.org/10.1186/s13063-020-04752-x

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