NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43

NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43

The TDP-43 is originally a nuclear protein but translocates to the cytoplasm in the pathological condition. TDP-43, as an RNA-binding protein, consists of two RNA Recognition Motifs (RRM1 and RRM2). RRMs are known to involve both protein-nucleotide and protein-protein interactions and mediate the fo...

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Bibliographic Details
Main Authors: Gilbert Nshogoza, Yaqian Liu, Jia Gao, Mingqing Liu, Sayed Ala Moududee, Rongsheng Ma, Fudong Li, Jiahai Zhang, Jihui Wu, Yunyu Shi, Ke Ruan
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetics
protein-RNA interaction
RRM domain inhibitor
NMR fragment-based screening
TDP-43
Online Access:https://www.mdpi.com/1422-0067/20/13/3230

Internet

https://www.mdpi.com/1422-0067/20/13/3230

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