Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway

Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway

Triple negative breast cancer (TNBC), characterized by its highly aggressive and metastatic features, is associated with poor prognosis and high mortality partly due to lack of effective treatment. Fisetin, a natural flavonoid compound, has been demonstrated to possess anti-cancer effects in various...

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Bibliographic Details
Main Authors: Jie Li, Xia Gong, Rong Jiang, Dan Lin, Tao Zhou, Aijie Zhang, Hongzhong Li, Xiang Zhang, Jingyuan Wan, Ge Kuang, Hongyuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
fisetin
triple negative breast cancer
EMT
PTEN
AKT
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00772/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00772/full

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