Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates

Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates

Aggregated forms of the synaptic protein α-synuclein (αS) have been proposed to operate as a molecular trigger for microglial inflammatory processes and neurodegeneration in Parkinson´s disease. Here, we used brain microglial cell cultures activated by fibrillary forms of...

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Bibliographic Details
Main Authors: Leonardo Acuña, Sabah Hamadat, Natalia S. Corbalán, Florencia González-Lizárraga, Mauricio dos-Santos-Pereira, Jérémy Rocca, Julia Sepúlveda Díaz, Elaine Del-Bel, Dulce Papy-García, Rosana N. Chehín, Patrick P. Michel, Rita Raisman-Vozari
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
aggregation
α-synuclein
microglia
neuroinflammation
Parkinson’s disease
cytokines
neuronal survival
Online Access:https://www.mdpi.com/2073-4409/8/8/776

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https://www.mdpi.com/2073-4409/8/8/776

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