EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

Summary: The integrity of the kidney filtration barrier essentially relies on the balanced interplay of podocytes and the glomerular basement membrane (GBM). Here, we show by analysis of in vitro and in vivo models that a loss of the podocyte-specific FERM-domain protein EPB41L5 results in impaired...

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Bibliographic Details
Main Authors: Jasmin I. Maier, Manuel Rogg, Martin Helmstädter, Alena Sammarco, Oliver Schilling, Benedikt Sabass, Jeffrey H. Miner, Jörn Dengjel, Gerd Walz, Martin Werner, Tobias B. Huber, Christoph Schell
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
EPB41L5
PDLIM5
podocyte
matrisome
extracellular matrix
ECM
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001972

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721001972

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