Umbilical mesenchymal stem cell-derived extracellular vesicles as enzyme delivery vehicle to treat Morquio A fibroblasts

Umbilical mesenchymal stem cell-derived extracellular vesicles as enzyme delivery vehicle to treat Morquio A fibroblasts

Abstract Background Mucopolysaccharidosis IVA (Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which results in the accumulation of the glycosaminoglycans (GAGs), keratan sulfate, and chondroitin-6-sulfate in th...

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Bibliographic Details
Main Authors: Michael Flanagan, Isha Pathak, Qi Gan, Linda Winter, Ryan Emnet, Salem Akel, Adriana M. Montaño
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Umbilical mesenchymal stem cell
Extracellular vesicles
Mucopolysaccharidosis IVA
Morquio A
Online Access:https://doi.org/10.1186/s13287-021-02355-0

Internet

https://doi.org/10.1186/s13287-021-02355-0

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