Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.

OBJECTIVES: REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. METHODS: Double-blind, parallel-group, international, randomised, non-inferiority trial. More than half of the 196 participating centres were primar...

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Main Authors: Geneviève Derumeaux, Laura Ernande, André Serusclat, Evelyne Servan, Eric Bruckert, Hugues Rousset, Stephen Senn, Luc Van Gaal, Brigitte Picandet, François Gavini, Philippe Moulin, REGULATE trial investigators
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3378581?pdf=render