Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol.

Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol.

<h4>Objective</h4>Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reve...

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Bibliographic Details
Main Authors: Susan Kühnast, Mieke C Louwe, Mattijs M Heemskerk, Elsbet J Pieterman, Jan B van Klinken, Sjoerd A A van den Berg, Johannes W A Smit, Louis M Havekes, Patrick C N Rensen, José W A van der Hoorn, Hans M G Princen, J Wouter Jukema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0066467

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https://doi.org/10.1371/journal.pone.0066467

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